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Progesterone & Premenstrual Syndrome
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- Dennerstein L, Spencer-Gardner C, Gotts G, Brown JB, Smith MA, Burrows GD. Progesterone and the premenstrual syndrome: a double blind crossover trial. Br Med J (Clin Res Ed) 1985 Jun 1; 290(6482): 1617-21.
In this double-blind, placebo-controlled randomized crossover trial, oral micronized progesterone demonstrated effectiveness in alleviating premenstrual complaints. Twenty-three women completed a Beck, et al depression inventory, Moos’s menstrual distress questionnaire, Spielberger, et al state anxiety inventory, and daily symptom diary before and during each treatment. There was an overall benefit of treatment for all variables, except positive moods, restlessness, and interest in sex. For most parameters, maximum benefit was seen within the first month of treatment, demonstrating an effectiveness of progesterone as a viable treatment option for women with PMS.
- Magill PJ. Investigation of the efficacy of progesterone pessaries in the relief of symptoms of premenstrual syndrome. Progesterone Study Group. Br J Gen Pract 1995 Nov; 45(400): 589-93.
This multi-center, prospective, double-blind, randomized parallel study undertook to compare progesterone vaginal suppositories (400 mg twice daily) with placebo for the relief of premenstrual symptoms. Ninety-three participants completed the study. A clinically and statistically significant reduction of symptoms was consistently demonstrated in the women receiving the suppositories who had experienced symptoms in the moderately to severe categories. Adverse events were slightly higher in the active group (51 vs. 43%) and were limited to headache, irregular bleeding, and vaginal itching.
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